VIA Disc

The VIA Disc NP is an off-the-shelf processed human nucleus pulposus tissue allograft intended to supplement degenerated intervertebral discs.

Disc Anatomy

The intervertebral disc (IVD) consists of three regions, the anulus fibrosus (AF), the nucleus pulposus (NP) and the cartilaginous endplate.

The AF is a fibrous outer ring of collagen fibers that functions as the primary load-bearing component of the IVD.

The NP is a hydrophilic gelatinous core comprised primarily of proteoglycans, collagen II, water and cells. The healthy NP contains ~77% water, and the high-water content provides the mechanical function of absorption and redistribution of spinal loads.

The endplates permit diffusion and provide the main source of nutrition for the disc.

Characteristics of Degenerated Discs

Degenerated discs are characterized by decreased disc height, loss of water content and loss of nutrient content.

These functional biomechanical alterations present as cracks and fissures within your disc. Altogether, the structural changes in the degenerated disc strain the nerves, put focal pressure on the spine and ultimately cause pain.

Discogenic Low Back Pain

Age-related wear and tear of the intervertebral discs can cause loss of hydration and degeneration. One of the most common causes of chronic low back pain is the degeneration of the disc. Not all degenerated discs cause pain, but painful disc degeneration most commonly occurs in the low back (or lumbar spine). The low lumbar spine carries a significant weight-bearing function and supports substantial rotational and translational movement, making the area susceptible to injury.
Discogenic low back pain can be determined through a combination of symptoms, physical examination and imaging. Pain typically manifests itself as medial back pain with or without radicular leg pain. Further identification focuses on determining the directional forces that worsen symptoms.With discogenic low back pain, shear forces push down and load the spine, applying pressure to the disc. Therefore, pain is exacerbated most when leaning forward as this weight-bearing position puts the most pressure on the painful disc.

Key Benefits of VIA DISC

  • Non-Surgical

    VIA Disc NP is a non-surgical option that can be delivered through a 22G spine needle.

  • Supplements the Disc

    In-vitro testing of nucleus pulposus tissue demonstrates ability of disc to absorb water similar to original nucleus pulposus tissue. Transplanted nucleus pulposus tissue may support biomechanical function of the supplemented disc.

  • Ease of Use

    Off-the-shelf allogeneic graft for ease
    of use.

  • Proprietary System for Allograft Preparation

    Consistent mixing in a fully closed system to reduce contamination risk.

How VIA Disc NP Works

Age-related wear and tear of the intervertebral disc can cause loss of hydration and degeneration.


VIA Disc NP is delivered into the degenerated intervertebral disc through a 22G spine needle.


After delivery, VIA Disc NP supplements the degenerated intervertebral disc.


VIA Disc NP utilizes proprietary technology to deliver disc supplementation.


NP particulate is derived from intervertebral discs of donor tissue, with the particulate size optimized for delivery into the disc.



Saline is mixed into the NP tissue for optimal hydration prior to delivery.



The VIA Disc NP procedure is a non-surgical intervention intended to supplement degenerated intervertebral discs. Transplanted tissue may support mechanical loading efficiency of the disc.

Risks and complications

Risks and complications may include:

  • Infection
  • Increased back pain
  • Bleeding
  • Nerve damage

Although risks related to VIA Disc NP Allograft are rare, serious complications can occur.

Credits & Sources:

  1. MedlinePlus
  2. MedicalNewsToday
  3. Vivex Website
  4. Zhu, Qiaoqiao: Numerical Modeling of Intervertebral Disc Degeneration and Repair (2016). Open Access Dissertations. Paper 1594.
  5. Walter BA, Torre OM, Laudier D, Naidich TP, Hecht AC, Iatridis JC. Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study. J Anat. 2015;227(6):707–716.
  6. Lundon K, Bolton K. Structure and Function of the Lumbar Intervertebral Disk in Health, Aging, and Pathologic Conditions. J Orthop Sports Phys Ther. 2001;31(6):291-306.
  7. Chen S, Fu P, Wu H, Pei M. Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function. Cell Tissue Res. 2017;370(1):53–70.
  8. Adams MA, McNally DS, Dolan P. 1996. Stress’ distributions inside intervertebral discs. The effects of age and degeneration. J Bone Joint Surg Br 78-B:965–972.
  9. Setton L, Chen J. Cell mechanics and mechanobiology in the intervertebral disc. Spine 2004; 29(13): 27, 10–23.
  10. Peng B, Wu W, Hou S, et al. The pathogenesis of discogenic low back pain. J Bone Joint Surg 2005; 87: 62–7.
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